NEWS FROM AROUND THE GLOBE BROUGHT TO YOU BY THE ICBC

Author: Frank Schuler

Frank Schuler is originally from Switzerland and reports on cannabis industry and policy news from around the world.
skin lotion

Clinical Trial Finds CBD More Effective Than Conventional Treatments At Treating Skin Ulcers

According to the American Cancer Society, skin cancer is the most common form of cancer. In fact, more than 1.5 million people were diagnosed with some form of skin cancer in the year 2020 alone.

It’s a serious health condition that is expected to only increase in prevalence going forward, with cases of skin cancer expected to increase as much as 50% around the world between now and 2040. Depending on the type of skin cancer a person has, and how severe it is, many cases of skin cancer are treatable.

Other skin conditions may be rarer compared to skin cancer and do not receive as much attention, however, they can still be very serious. One such skin condition is scleroderma, which involves inflammation of the skin. Some patients develop skin ulcers as a result of scleroderma.

Researchers in Italy recently examined CBD topical’s ability to treat skin ulcers, and they found that CBD topicals were more effective compared to conventional treatments. Below is more information about it via a NORML news release:

Modena, Italy: The administration of a topical extract preparation of CBD effectively mitigates wound-related pain and promotes the healing of skin ulcers in patients with scleroderma, according to randomized trial data published in the journal Advances in Skin & Wound CareScleroderma (a/k/a systemic sclerosis) is a rare autoimmune disorder involving the tightening of the skin and the narrowing of blood vessels.

Italian investigators assessed the efficacy of topical CBD oil compared to conventional medications in a group of scleroderma patients with digital ulcers (skin ulcers of the fingertips). Twenty-five patients were randomly selected to use CBD for one month; the other 20 received conventional therapy.

Subjects in the CBD group experienced greater pain relief and wound healing than did those in the control group. Authors reported, “Although mean wound-related pain NRS [numeric rating scale] scores did not differ between CBD-treated patients and control patients at baseline, their mean scores differed significantly after 1 month.” Specifically, patients in the treatment group experienced a decrease in pain of 29 percent over the course of the trial, whereas those in the control group only experienced a six percent decrease.

Investigators further acknowledged, “In terms of DU [digital ulcer] healing, 18 of the 25 patients in the CBD-treated group (72 percent) experienced complete healing by the end of the study. In contrast, complete healing was observed in (only) 6 of the 20 control group participants (30 percent).”

Patients receiving CBD treatment reported “no significant adverse effects” during the study.

“The present study is the first to report the effectiveness of local CBD treatment in the management of SSc-DUs [systemic sclerosis digital ulcers],” authors concluded.  “Topical administration of CBD is a safe, effective, noninvasive tool that is associated with improved wound-related pain, DU healing, and QoL [quality of life] of patients with SSc.”

The topical application of cannabinoids, and of CBD in particular, has demonstrated benefits in the treatment of a variety of skin-related conditions, including psoriasiserythemapruritis, and acne. It has also been associated with wound healing in patients with refractory leg ulcers and with the rare skin blistering disease epidermolysis bullosa.

Full text of the study, “Topical cannabidiol in the treatment of digital ulcers in patients with scleroderma: Comparative analysis and literature review,” appears in Advances in Skin & Wound Care.

 

italy

cannabis joint flower preroll prerolls

UK Study Finds That Cannabis Is Associated With Improvements In Depressive Symptoms

Depression is a common mental health condition affecting people all over the globe. Major depressive disorder, or depression as it is more often referred to, negatively affects how people feel, think, and act.

The condition can be caused by any number of things, or combination of things, including deficient mood regulation by the patient’s brain, genetic susceptibility, grief, and/or stressful events that have occurred in the person’s life.

Common symptoms include sadness, loss of interest in things the patient previously enjoyed, changes in appetite, insomnia, loss of energy, difficulty focusing, and/or thoughts of death or suicide.

Fortunately, depression can be treated, with the cannabis plant being increasingly used by patients to help battle depression. A team of researchers in the United Kingdom recently examined cannabis use by patients suffering from depression and the results are encouraging. Below is more information about it via a NORML news release:

London, United Kingdom: The daily consumption of cannabis products is associated with sustained improvements in depressive symptoms, according to observational trial data published in the journal Expert Review of Neurotherapeutics.

British investigators assessed the safety and efficacy of cannabis products in 129 subjects with a primary diagnosis of depression. Study subjects were participants in the UK Medical Cannabis Registry and all possessed a doctor’s authorization to consume cannabis. Study participants consumed either cannabis extracts, THC-dominant flowers, or both for a period of six-months.

Researchers reported: “The results showed that medicinal cannabis was associated with improvements in depression and anxiety symptoms, as well as health-related quality of life, and sleep quality after 1, 3, and 6 months of treatment.” While some subjects reported adverse events from cannabis products, almost all side effects were classified as either “mild or moderate.”

Authors concluded, “Future studies could focus on conducting controlled observational studies or pilot trials to determine the potential of CBMPs [cannabis-based medicinal products] as a treatment for depression.”

Post-traumatic stress patients enrolled in the UK Medical Cannabis Registry have similarly shown sustained symptomatic improvements following cannabis therapy.

Full text of the study, “Assessment of clinical outcomes of medicinal cannabis therapy for depression: Analysis from the UK Medical Cannabis Registry,” appears in the Expert Review of Neurotherapeutics.

uk, United Kingdom

back pain

Cannabis Compounds Effective At Mitigating Chronic Pain And Improving Sleep According To New Study

Neuropathic pain is a major health condition affecting a significant percentage of the global population. Neuropathic pain involves a patient’s nervous system being damaged or not working correctly due to various reasons.

Common causes of neuropathic pain include, but are not limited to, nerve pressure or nerve damage after surgery or trauma, infections, cancer, extreme alcohol use, and conditions such as multiple sclerosis and diabetes.

A common condition that accompanies chronic neuropathic pain is an inability to gain proper sleep. Neuropathic pain patients often report difficulty falling asleep and/or staying asleep, largely due to the pain that they are experiencing.

A team of researchers in Canada recently examined randomized controlled trial data involving neuropathic pain, sleep, and medical cannabis use and the results of their research was very insightful. Below is more information about it via a news release from NORML:

Toronto, Canada: Cannabis compounds are effective at mitigating chronic neuropathic pain and improving sleep, according to a review of randomized controlled trial data published in the journal Regional Anesthesia & Pain Medicine.

A team of Canadian researchers evaluated results from nine trials that compared synthetic and natural cannabinoids to placebo in patients suffering from neuropathic pain syndromes.

They reported: “Meta-analysis of data from six studies showed that cannabinoids were associated with a significant improvement in sleep quality. Meta-analysis of data from eight studies showed a significant reduction in daily pain scores in the cannabinoid group.”

Authors concluded: “Cannabinoids have a role in treating chronic neuropathic pain as evidenced by significant improvements in sleep quality, pain intensity, and PGIC [Patients’ Global Impression of Change scale]. More research is needed to comprehensively evaluate the impact of cannabinoids on sleep health and analgesic efficacy.”

Survey data consistently reports that patients who use cannabis products typically do so to mitigate chronic pain and improve sleep. Among patients in US states where medical cannabis access is permitted, over 60 percent are qualified to use it to treat pain.

Full text of the study, “Evaluating the impact of cannabinoids on sleep health and pain in patients with chronic neuropathic pain: A systematic review and meta-analysis of randomized controlled trials,” appears in Regional Anesthesia & Pain MedicineAdditional information on cannabis and chronic pain is available from NORML’s publication, Clinical Applications for Cannabis & Cannabinoids.

Canada

united states flag

What Were The Top U.S. Cannabis Policy Stories In 2022?

The United States has historically led the charge when it comes to global cannabis prohibition, so any time cannabis policies are reformed in the U.S. it’s good news for the rest of the world, in addition to being good news domestically.

Unfortunately, 2022 did not yield national legalization in the U.S. as many cannabis advocates had hoped, however, there were still many notable victories. Below is NORML’s top ten cannabis policy events from 2022 per a news release:

#1: THREE MORE STATES ENACT ADULT-USE LEGALIZATION LAWS

Voters and lawmakers in three more states — MarylandMissouri, and Rhode Island — enacted laws in 2022 legalizing adult-use marijuana possession and regulating retail cannabis markets. Voters in Missouri voted in favor of a constitutional amendment while Maryland voters approved a legislative referendum. Rhode Island’s law was enacted by the legislature. In total, 21 states — comprising nearly one-half of the US population — have now adopted laws regulating adult use marijuana production and retail sales.

“Reformers achieved numerous significant legislative victories in 2022,” NORML’s Executive Director Erik Altieri said. “As more lawmakers recognize that advocating for marijuana policy reforms is a political opportunity, not a political liability, we anticipate future legislative gains in 2023 and beyond.”

#2: TENS OF THOUSANDS OF AMERICANS RECEIVE MARIJUANA-SPECIFIC PARDONS AND EXPUNGEMENTS

The President of the United States and several state officials issued mass pardons and expungements in 2022 to those with prior low-level cannabis convictions. In October, President Joe Biden granted pardons to over 6,500 people with federal marijuana possession convictions. In ConnecticutColoradoOregon and elsewhere, officials issued over 100,000 marijuana-related pardons and expungements. To date, two dozen states have enacted legislation explicitly facilitating the expungement of prior marijuana-specific convictions. As a result of these laws, NORML estimates that 2 million Americans have had their cannabis-related convictions set aside in recent years.

“Hundreds of thousands of Americans unduly carry the burden and stigma of a past conviction for behavior that most Americans, and a growing number of states, no longer consider a crime,” NORML’s Deputy Director Paul Armentano said. “Our sense of justice and our principles of fairness demand that public officials and the courts move swiftly to right the past wrongs of cannabis prohibition and criminalization.”

#3: SENATE FAILS TO MOVE SAFE BANKING ACT

The 117th Congress adjourned without members of the US Senate holding any hearings or votes on either the Secure and Fair Enforcement (SAFE) Banking Act or other significant pieces of marijuana reform legislation. Since 2019, House members have advanced the legislation on seven separate occasions. The Senate companion bill had 42 co-sponsors, including nine Republicans.

“It is unfortunate that Congress, and members of the US Senate specifically, failed to take this opportunity to affirm the legitimacy of state-legal marijuana markets and instead acted in a way that will continue to deny this emerging legal industry access to basic financial tools and services,” said NORML’s Political Director Morgan Fox. “Until Congressional action is taken, state-licensed marijuana businesses, the hundreds of thousands of people they employ, and the millions of Americans that patronize them will continue to be at a higher risk of robbery due to the cash-heavy nature of this industry created by outdated federal laws. Furthermore, smaller entrepreneurs who seek to enter this industry will continue to struggle to compete against larger, more well-capitalized interests.”

Prior to the 2020 election, Sen. Chuck Schumer – then Minority Leader – pledged on multiple occasions that he would prioritize bringing legislation to repeal the federal criminalization of cannabis to a floor vote.

#4: MORE LAWMAKERS ENACT WORKPLACE PROTECTIONS FOR CANNABIS CONSUMERS

State lawmakers adopted numerous laws in 2022 limiting employers’ ability to either fire or refuse to hire employees solely based upon their off-the-job marijuana use. Specifically, lawmakers in California, the District of Columbia, and Rhode Island prohibited employers from discriminating against workers who test positive for carboxy-THC on a drug test, while protections for patients were enacted in several other states (e.g., Louisiana, Missouri, and Utah). In total, eight jurisdictions — California, Connecticut, the District of Columbia, Nevada, New Jersey, New York, Montana, and Rhode Island — have enacted statutes limiting employers’ ability to hire/fire workers for their recreational cannabis use in certain circumstances, while more than half of medical marijuana access states have enacted similar workplace protections.

“These decisions reflect today’s changing cultural and legal landscape surrounding cannabis,” NORML’s Deputy Director Paul Armentano said. “It is time for workplace policies to adapt to this new reality and to cease punishing employees for activities they engage in during their off-hours that pose no legitimate threat to either workplace safety or productivity.”

#5: HISTORIC PERCENTAGES OF AMERICANS SAY CANNABIS SHOULD BE LEGALIZED

The percentage of Americans who support adult-use cannabis legalization remains at record highs. National survey data compiled by Data for Progress reported that 74 percent of likely voters now “support ending the federal ban on marijuana.” For the third consecutive year, polling data compiled by Gallup found that 68 percent of US adults say that “the use of marijuana should be legal.” Separate polls released this year by Fox News, Monmouth University, YouGov, Politico, and several others similarly reported that most Americans back legalizing cannabis.

“There is no buyer’s remorse on the part of the American people,” NORML’s Executive Director Erik Altieri said. “In the era of state-level legalization, voters’ support for this issue has grown rapidly — an indication that these policy changes have been successful and are comporting with voters’ desires and expectations.”

#6: FBI FAILS TO PROVIDE COMPREHENSIVE MARIJUANA ARREST FIGURES FOR THE FIRST TIME

Data provided in October by the US Federal Bureau of Investigation reported that in 2021 over 400,000 drug-related seizures involved cannabis; however, for the first time in decades the agency failed to provide national estimates regarding the number of people arrested for marijuana-related violations. Data previously provided by the FBI has allowed NORML to track yearly marijuana-related arrests since 1965.

“At a time when voters and their elected officials nationwide are re-evaluating state and federal marijuana policies, it is inconceivable that government agencies are unable to produce any explicit data on the estimated costs and scope of marijuana prohibition in America,” NORML’s Deputy Director Paul Armentano said.

#7: POTUS SIGNS LAW FACILITATING CLINICAL CANNABIS TRIALS AND DRUG DEVELOPMENT

President Joe Biden signed legislation into law facilitating the federal approval of cannabis-specific clinical research and drug development. It is the first time in over 50 years that a President has signed a stand-alone piece of legislation loosening federal marijuana prohibitions.

Under the new law, the US Attorney General is provided with a 60-day timeline to either approve or deny applications from scientists wishing to conduct clinical trials involving the use of cannabis by human subjects. The law also mandates the US Attorney General to solicit applications from those seeking to grow cannabis for either research purposes or for potential drug development, and it provides a timeline for the AG to approve those applicants. It also calls upon federal agencies, including HHS, to provide a report on the “potential therapeutic effects of cannabidiol or marijuana on serious medical conditions.”

NORML’s Political Director Morgan Fox said, “While the significance of POTUS signing the first stand-alone cannabis policy reform bill should not be overlooked, in truth, we don’t need more research to know definitively that prohibition is a misguided and disastrous policy.” He added: “That said, this legislation is certainly a step in the right direction that shows there can be bipartisan cooperation on this issue.”

With advocates facing a divided Congress in 2023, virtually any efforts to advance cannabis-specific reform legislation would require bipartisan support.

#8: ANALYSIS: STATE-LEGAL MARIJUANA INDUSTRY EMPLOYS OVER 428,000 FULL-TIME WORKERS

The state-licensed cannabis industry added over 100,000 new jobs in 2021 and now employs over 428,000 full-time workers, according to data compiled in February by Leafly.com and Whitney Economics.

According to its latest report, the cannabis industry created an average of 280 new jobs per day in 2021. That represents a 33 percent year-over-year increase, and it marks the fifth year in a row of annual jobs growth greater than 27 percent.

“At a time when the rest of the economy is struggling and people are leaving their jobs in droves, the legal cannabis industry is blooming, showing exponential employment growth, and attracting talented and driven individuals from across the workforce,” NORML’s Political Director Morgan Fox said.

#9: SURVEY: OVER 90% OF PAIN PATIENTS REPORT REDUCING THEIR OPIOID INTAKE FOLLOWING MEDICAL CANNABIS

The overwhelming majority of pain patients provided medical cannabis treatment report either reducing or ceasing their use of opioid medications, according to data published in August in the Journal of Addictive Diseases.

A team of Israeli investigators affiliated with Tel Aviv University assessed the relationship between cannabis and opioids in a cohort of patients with non-cancer specific chronic pain. All of the patients enrolled in the study were prescribed medical cannabis therapy in accordance with Israel’s medical cannabis access laws. Among those patients who reported using opioids at baseline, 93 percent either “decreased or stopped [using] opioids following cannabis initiation” – a finding that is consistent with dozens of other studies involving numerous other patient populations.

“The data is clear and consistent,” NORML’s Deputy Director Paul Armentano said. “Cannabis is effective in treating a variety of forms of chronic pain and, for some patients, it provides a viable alternative to potentially deadly opioids.”

#10: MISSISSIPPI BECOMES 37TH STATE TO LEGALIZE MEDICAL CANNABIS ACCESS

State lawmakers passed comprehensive legislation in February regulating the production and dispensing of medical cannabis products. The legislation was enacted 15 months after state voters initially passed a similar medical marijuana legalization initiative. However, the courts later struck down the state’s citizens’ initiative process – thus nullifying the 2020 election result.

“Marijuana access has been long overdue for Mississippi’s patients,” NORML’s State Policies Manager Jax James said. “The overwhelming majority of voters decided in favor of this policy change two years ago, and while lawmakers cannot make up for lost time, they have an obligation to roll out this program as swiftly as possible so that patients can finally access the medicine they need.”

united states

bed rest nap sleep insomnia

Clinical Trial Finds Cannabis Oil To Be Effective At Treating Insomnia

Insomnia may not seem like a serious health condition to some people, however, anyone that suffers from significant insomnia will be quick to point out that it can have a negative impact on a person’s life.

The Mayo Clinic defines insomnia as, “a common sleep disorder that can make it hard to fall asleep, hard to stay asleep, or cause you to wake up too early and not be able to get back to sleep.” Chronic insomnia occurs when the condition lasts longer than a month.

In addition to making a person feel tired throughout the day, insomnia can also be an indicator of one or more other serious health conditions. Researchers in Australia recently conducted a clinical trial involving cannabis extracts and insomnia patients, and their findings are encouraging. Below is more information via a news release from NORML:

Melbourne, Australia: The short-term use of plant-derived cannabis extracts is well-tolerated and effective in patients diagnosed with insomnia, according to placebo-controlled trial data published in the Journal of Sleep Research.

Australian researchers assessed the use of a proprietary cannabis oil product (Entoura-10:15) versus placebo in 29 subjects with chronic insomnia. Extracts contained 10mg of THC and 15mg of CBD. Participants consumed either extracts or placebo for a period of two weeks.

Investigators reported that those receiving cannabis extracts experienced improved sleep quality by up to 80 percent, and that “60 percent of participants no longer classified as clinical insomniacs at the end of the two-week intervention period.”

They concluded: “Our short-term trial suggests Entoura 10:15 medicinal cannabis oil, containing THC:CBD 10:15 and lesser amounts of other CBs and naturally occurring terpenes, to be well tolerated and effective in significantly improving sleep quality and duration, midnight melatonin levels, quality of life, and mood within 2-weeks in adults with insomnia. … Long-term studies are needed to assess whether chronic medicinal cannabis intake can restore natural circadian rhythm without the need for ongoing cannabis intake.”

The results are similar to those of a prior placebo-controlled clinical trial, published in 2021, that also reported that plant-derived cannabis extracts are “well tolerated and improve insomnia symptoms and sleep quality in individuals with chronic insomnia symptoms.” Observational trials similarly report benefits in patients’ sleep quality following the inhalation of cannabis flowers prior to bedtime.

Full text of the study, “Medicinal cannabis improves sleep in adults with insomnia: A randomized double-blind placebo-controlled crossover trial,” appears in the Journal of Sleep Research. Additional information on cannabis and insomnia is available from NORML’s publication, Clinical Applications for Cannabis & Cannabinoids.

australia, insomnia

australia

Researchers In Australia Find Oral Cannabis Products To Be Safe And Effective

Oral cannabis products have grown in popularity and availability in recent years. Many patients still prefer to consume medical cannabis in edible or inhaled form, however, some patients need to have smokeless options in forms that do not require chewing and other effort that is hard for some patients.

Many oral cannabis products have a long shelf life, are easy to transport and store, and provide a specific dosage of cannabinoids that many patients’ conditions and situations require. Oral cannabis products are not for every patient in every situation, yet they are a great option for many.

One lingering question that accompanies any new form of medicine is, ‘is it safe and effective?’ A team of researches in Australia recently explored the long-term safety and efficacy of oral cannabis products and the results were encouraging. Below is more information about it via a news release from NORML:

Western Australia, Australia: Patients authorized to consume plant-derived oral cannabis products show sustained improvements in their symptoms, according to longitudinal data published in the journal PLOS One.

Researchers assessed the long-terms safety and efficacy of oral cannabis products in a cohort of nearly 4,000 Australian patients authorized to use them. Study participants were naïve to cannabis prior to their enrollment in the trial. The majority of the study’s subjects (64 percent) suffered from chronic pain conditions. All of the study’s participants consumed oral cannabis products for a period of two years.

Investigators reported: “This is the largest and longest real-world analysis of the efficacy and safety of GMP [good manufacturing practices]-like oral medicinal cannabis (MC) in a continuous enrolment cohort registry. 3,961 heterogenous, cannabis naïve patients with a wide range of ages, clinical and complex conditions, and concomitant medications, prescribed oral MC, demonstrated a rapid and significant improvement across all measured patient and clinical reported validated outcomes. … Oral MC was well tolerated. … This safety is particularly salient in contrast to the safety and tolerability of prescribed long-term opioids.”

They concluded, “This large Australian longitudinal cohort registry of cannabis naïve, complex chronic disease patients treated with oral MC for over 24 consecutive months, demonstrates safety of oral generic medicinal cannabis, and demonstrated oral MC improves patient and clinician reported impact of pain, sleep and well-being.”

An estimated 100,000 Australians have been prescribed cannabis products following the enactment of legal changes in 2016 providing patients with regulatory access to medical marijuana products.

Full text of the study, “A large Australian longitudinal cohort registry demonstrates sustained safety and efficacy of oral medicinal cannabis for at least two years,” appears in PLOS One.

australia

blood pressure hypertension heart health

Italian Researchers Examine Cannabis Spray And Stroke Survivors

According to the World Stroke Organization it is estimated that over 12 million people experience a stroke in any given year, and that as many as one out of every four people over 25 years old will have a stroke at some point during their life.

A stroke is defined by the Mayo Clinic as occurring when, “the blood supply to part of the brain is interrupted or reduced, preventing brain tissue from getting oxygen and nutrients.” Brain cells can begin to die very quickly when deprived of oxygen and nutrients.

Life after experiencing a stroke can be difficult for those that live through it, with many stroke survivors experiencing some level of paralysis due to the stroke. Post-stroke treatments can involve physical therapy and various medications.

A treatment that is growing in popularity is cannabis, and according to a recent study in Italy, at least one form of cannabis treatment appears to be safe for stroke survivors based on researchers’ findings. Below is more information about it via a news release from NORML:

Genova, Italy: The daily consumption of a proprietary oromucosal spray containing equal ratios of plant-derived THC and CBD (nabiximols aka Sativex) is not associated with cardiovascular complications in stroke survivors, according to clinical data published in the journal Frontiers in Cardiovascular Medicine.

A team of Italian researchers assessed the safety of nabiximols in a cohort of 34 spasticity patients that had previously suffered from strokes.

Investigators reported: “No cardiovascular treatment-emergent adverse drug effects emerged during nabiximols treatment, namely no significant fluctuation of blood pressure and heart rate, nor ischemic or hemorrhagic events occurred. During nabiximols treatment, self-assessed blood pressure and heart rate did not change compared to the baseline condition. No patients showed significant acceleration or decrease in heart rate or change in rhythm and none required an additional ECG or cardiological evaluation during the study.”

They concluded, “These data support the cardiovascular safety of nabiximols.”

Analyses of nationally representative samples of recreational marijuana consumers have reported inconsistent results regarding the relationship between cannabis and adverse cardiovascular events. A 2021 study of 57,000 US adults concluded, “After controlling for several confounding variables, we found that there was a decrease in the prevalence of cardiovascular events with marijuana use (Odds Ratio: 0.74).” By contrast, a 2020 review of nearly 134,000 US adults reported, “Frequent marijuana smoking is associated with significantly higher odds of stroke and myocardial infarction or coronary artery disease, with a possible role in premature cardiovascular disease.”

More recently, the results of a literature review of 67 studies published in The American Journal of Medicine concluded, “[M]arijuana itself does not appear to be independently associated with excessive cardiovascular risk factors.” Authors did caution, however, that “it can be associated with other unhealthy behaviors such as alcohol use and tobacco smoking that can be detrimental” to cardiovascular health.

Similarly, a separate review published last year of 46 randomized clinical trials involving 2,800 patients concluded that consumption of either purified or synthetic cannabinoids, including THC, is not associated with any increased risk of serious cardiovascular events.

Full text of the study, “Nabiximols effect on blood pressure and heart rate in post-stroke patients of a randomized controlled study,” appears in the journal Frontiers in Cardiovascular Medicine.

italy

canada flag

Health Canada Releases 2022 Canadian Cannabis Survey

Canada was not the first country to pass a nationwide cannabis adult-use legalization measure, however, it was the first G-7 nation to do so, and remains the only country on earth where anyone of legal age can legally purchase cannabis regardless of residence status.

The only other two countries that have passed national legalization measures are Uruguay and Malta. Uruguay is the only country to pass such a measure prior to Canada doing so, yet, legal sales are only permitted to residents. Malta does not currently have a regulated industry.

With all of that in mind, Canada provides the best legalization model for industry research purposes, particularly regarding how a regulated industry affects usage rates in society. Canada’s annual survey results are out, with more information about it below via a government news release:

OTTAWA, ONDec. 16, 2022 /CNW/ – The Government of Canada collects data to better understand how Canadians view and use cannabis. Through this data, we can better monitor Canada’s national framework for controlling the production, distribution, sale and possession of cannabis under the Cannabis Act.

Today, Health Canada published the results of the 2022 Canadian Cannabis Survey. Health Canada has conducted the Canadian Cannabis Survey every year since 2017. The 2022 survey is the sixth cycle of the survey, and data were collected from April to June 2022.

Key findings from the 2022 Canadian Cannabis Survey include:

  • Past 12-month cannabis use among youth aged 16-19 has returned to pre-legalization levels in 2021 and 2022, after increasing between 2018 and 2020.

  • Overall, proportions of those reporting daily or almost daily cannabis use among those who use cannabis (an indicator of problematic or high-risk cannabis use behaviour) have been stable since 2018, including among youth aged 16-19.

  • The percentage of those classified at ‘high-risk’ of developing problems from their cannabis use has remained stable since 2018.

  • The proportion of respondents smoking cannabis have continued to decline since 2018 while vapourizing cannabis using a vape pen has increased since 2021.

  • Smoking is still the most common method of consuming cannabis, followed by eating and vapourizing with a vape pen or e-cigarette.

  • A greater proportion of respondents reported a legal source as their usual source of cannabis compared to 2021, with legal storefronts being the most common source since 2019. A smaller proportion reported illegal storefronts and illegal online sources in 2022 compared to 2019.

  • Among those who used cannabis, driving after recent use decreased between 2018 and 2021 and remained unchanged in 2022.

  • More than a quarter of those who used cannabis for medical purposes said they did so with a document from a healthcare professional, an increase since 2021.

Results of the Canadian Cannabis Survey will be used to inform policy and program development, and help target public education and awareness activities. The data from the survey will also help inform the legislative review of the Cannabis Act, which is being led by an independent expert panel.

This important survey complements Health Canada’s other national substance use surveys, including the Canadian Alcohol and Drugs Survey and the Canadian Student Tobacco, Alcohol and Drugs Survey.

Quick Facts

  • The 2022 CCS results are based on online responses from approximately 10,000 respondents aged 16 years of age and older from each province and territory.
  • Data were collected across five themes:
    • knowledge, attitudes and behaviours;
    • cannabis use and products used;
    • sources of cannabis and purchasing patterns;
    • driving and cannabis use; and
    • cannabis for medical purposes.
  • The 2022 survey collected new data on the following topics:
    • accidental consumption of cannabis products by individuals and pets in the household (to note: while the percentage people reporting accidental consumption in their home is small (1%), this would still result in a large number of events throughout the population);
    • exposure to advertisements or promotions of cannabis; and,
    • changes in cannabis use over the past 12 months in the context of the ongoing COVID-19 pandemic.

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Canada

ptsd pain headache migraine

UK Study Finds PTSD Symptoms Improved After Cannabis Use

Post-traumatic stress disorder is a major public health issue all over the world. The prevalence of post-traumatic stress disorder (PTSD) is estimated to be 3.9% in the general population, and a much higher rate for those that have lived in countries where war and conflict has occurred.

According to the Mayo Clinic, “Post-traumatic stress disorder (PTSD) is a mental health condition that’s triggered by a terrifying event — either experiencing it or witnessing it.”

As with most health conditions, there are varying degrees of severity when it comes to PTSD, ranging from mild anxiety all the way to full blown panic attacks occurring regularly to the point that the patient can’t function. Flashbacks and regular nightmares are also symptoms of PTSD.

Fortunately, the cannabis plant has been found by a growing list of studies to help people that suffer from PTSD. A recent study in the United Kingdom found that cannabis use is associated with improved symptoms among patients suffering from PTSD. Below is more information about it via a news release from NORML:

London, United Kingdom: Patients with post-traumatic stress experience symptom improvements following the use of cannabis products, according to data published in the journal Expert Review of Neurotherapeutics.

British investigators assessed the safety and efficacy of cannabis products in 162 PTSD patients with a physician’s authorization. Study subjects were participants in the UK Medical Cannabis Registry. Study participants consumed either cannabis extracts or THC-dominant flowers for a period of six-months.

Authors reported that patients showed “statistically significant improvements” in a variety of domains, including sleep, anxiety, and stress. Self-reported adverse events were typically mild in severity.

“This observational study suggests an association between CBMP [cannabis-based medicinal products] treatment and improvement in PTSD-specific, HRQoL [health-related quality of life], sleep, and anxiety outcomes at up to 6-month follow-up,” they concluded. “CBMPs were well-tolerated and adverse events manageable. … [T]his study can serve to inform future randomized placebo-controlled trials with the aim of confirming these promising effects, whilst informing current clinical practice.”

Observational studies assessing the role of cannabinoids in mitigating symptoms of PTSD have generally yielded mixed results. A 2021 clinical trial reported that the inhalation of marijuana flowers provided limited benefits compared to placebo in treating symptoms of PTSD.

Full text of the study, “Assessment of clinical outcomes in patients with post-traumatic stress disorder: Analysis from the UK Medical Cannabis Registry,” appears in the journal Expert Review of Neurotherapeutics. Additional information on cannabis and post-traumatic stress is available from NORML’s publication, Clinical Applications for Cannabis & Cannabinoids.

ptsd, uk, United Kingdom

beer alcohol

Study Finds Medical Cannabis Reform In Canada Associated With Reduced Alcohol Sales

A study in 2015 found that cannabis is 114 times safer than alcohol. That, of course, highlights some of the irony behind cannabis still being illegal in many parts of the world, even for medical use, while alcohol is legal in nearly all (if not all) of those same countries.

This is not to say that alcohol should be prohibited. Much like cannabis prohibition, alcohol prohibition does not work and results in more harm than good. Just as people can and should be able to consume cannabis responsibly, so too should they be able to do so with alcohol.

With that being said, cannabis is exponentially safer compared to alcohol, so any reduction in alcohol use is a good thing overall for society from a public health standpoint. According to a recent study in Canada, medical cannabis reform is associated with reduced alcohol sales. Below is more information about it via a news release from NORML:

Ontario, Canada: The adoption of medical cannabis access in Canada was associated with reductions in alcohol sales, according to data published in the journal Health Policy.

A Canadian researcher evaluated the relationship between medical cannabis legalization and retail sales of alcohol in various regions of the country over an eight-year period.

The author determined: “This study found a significant negative association between legal medical cannabis sales and liquor store alcohol sales: each cannabis sales dollar was associated with an average alcohol sales reduction of between $0.74 and $0.84. The negative association was robust with respect to several alternative modeling choices.”

He concluded, “From a public health perspective, the results likewise imply that reductions in alcohol-related health impacts might partly offset the increased cannabis-related health impacts that legalization might bring.”

A 2017 analysis of US beverage sales identified a similar decline in alcohol sales following the adoption of statewide medical cannabis legalization laws, as did a 2021 assessment of Youth Risk Behavioral Survey data. By contrast, a more recent study evaluating the impact of adult-use legalization laws in the United States reported an association with increased alcohol use those age 21 and older.

Full text of the study, “Relationship between sales of legal cannabis and alcohol in Canada,” appears in Health Policy.

Canada

cannabis joint preroll

Australian Researchers Find Lacking Evidence To Support Cannabis ‘Hangover’ Claims

When cannabis opponents speak out against cannabis they incorporate a variety of talking points, with some being more ridiculous than others. It seems as if some opponents will do or say just about anything to portray cannabis use in a negative fashion.

One argument that seems to be deployed at an increasing rate is that ‘cannabis causes hangovers.’ In an example of the sad hypocrisy that often accompanies anti-cannabis propaganda, very rarely, if ever, do those same cannabis opponents call for an end to alcohol sales due to hangovers.

Furthermore, while there is ample evidence that alcohol use can result in hangovers, researchers in Australia have found that the same is not true for cannabis, despite what cannabis opponents may claim. Below is more information about it via a news release from NORML:

New South Wales, Australia: The majority of available data fails to support claims that cannabis may potentially impact either cognitive function or subjects’ performance of safety sensitive tasks 24 hours after consumption, according to a review of the scientific literature published in the journal Cannabis and Cannabinoid Research.

A team of Australian researchers reviewed data from 20 studies involving 458 subjects. Selected studies assessed subjects’ performance 12 to 24 hours following THC dosing.

Investigators failed to identify any evidence of so-called THC-specific “next-day effects” in 16 of the 20 studies reviewed.

They concluded: “A small number of lower-quality studies have observed negative (i.e., impairing) ‘next day’ effects of THC on cognitive function and safety-sensitive tasks. However, higher-quality studies, and a large majority of performance tests, have not. Overall, it appears that there is limited scientific evidence to support the assertion that cannabis use impairs ‘next day’ performance.”

Authors further opined that the imposition of workplace drug testing policies that detect the long-term presence of cannabis metabolites and impose sanctions upon those who test positive for them are arguably not justified by the available data.

Full text of the study, “The ‘next day’ effects of cannabis use: A systematic review,” appears in Cannabis and Cannabinoid ResearchAdditional information is available in NORML’s fact sheet, ‘Marijuana Legalization and Impact on the Workplace.’

australia

frankfurt germany

Head Of Frankfurt Drug Department Calls For German Legalization

All eyes remain on Germany where the adult-use legalization effort continues. For those that may not be up to speed, back in October the framework for a long-awaited legalization measure was presented by Germany’s Commissioner on Narcotic Drugs at the Federal Ministry of Health Burkhard Blienert to the nation’s federal cabinet.

Since the formal presentation, Commissioner Blienert has spent time lobbying and educating the European Union in an effort to gain the body’s approval for Germany to proceed with the legalization plan. Blienert previously announced that he will be seeking ‘an expert opinion’ to help with the EU approval push.

In the meantime, the legalization effort is yielding public comments on both sides of the issue, with a notable voice expressing full support for the legalization plan. Artur Schroers, head of the Frankfurt Drug Department, recently participated in a civic interview and made it clear how he feels about the federal legalization plan.

“We would welcome it if cannabis were given to adults for recreational purposes under state-controlled conditions, instead of users obtaining substances on the criminal black market from dealers. Users would be decriminalized, destigmatized and would not have to worry about contamination or the like with state-certified cannabis. A controlled delivery would enable quality control and transparency about the THC content for the first time.” Schroers stated in the interview (translated from German to English).

“The protection of young people and health could also be significantly improved with state awarding agencies or licensed specialist shops. With this in mind, we support plans for the controlled distribution of cannabis and are preparing to that we can professionally meet the expected demand with the associated need for advice and prevention offers for young people. When it finally starts also depends on whether and when the European Commission approves the planned law. Of course, there are voices who want to see a new wave of drugs in cannabis legalization. But if you look at Canada or the USA, you will see that legalization has not increased the number of young people using drugs.” Schroers also stated.

“What always bothers me about the debate is the legal gap in people’s minds when assessing the harmfulness of individual substances, which also applies to the distinction between supposedly hard and soft drugs. Far more people die every year from the consequences of alcohol consumption than from the consequences of many other addictive substances. But in our society it was the case for decades that tobacco and alcohol were seen as stimulants and everything else was “the devil’s stuff”. Whether legal or illegal – the risk assessment should be based less on legal assessments and more on the actual toxicological, social and individual psychosocial risk potential.” Schroers went on to say.

Artur Schroers makes a lot of good points, and given his profession and standing, hopefully lawmakers across Germany and the rest of the EU are listening.

Germany

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